PSC has established a practical profiling method for comprehensive analysis of sulfur-containing secondary metabolites (S-omics) using Fourier transform ion cyclotron resonance-mass spectrometry (FTICR-MS).
Many of the chemical compounds found in pharmaceuticals derive from naturally occurring secondary metabolites in plants and often contain heteroatoms (N, O, S or halogen elements). Secondary metabolites containing sulfur have received particular attention because of their health-promoting potential. Our S-omics profiling method establishes an effective way to search for sulfur-containing secondary metabolites beneficial to humans. The application of S-omics will enable easy searches of other plants and makes possible analysis of other heteroatom-containing metabolites, and the method should prove to be a useful tool for discovering a wide variety of metabolites.
Analytical Chemistry, dx.doi.org/10.1021/ac302733c.
Ryo Nakabayashi, Yuji Sawada, Yutaka Yamada, Makoto Suzuki, Masami Yokota Hirai, Tetsuya Sakurai, Kazuki Saito
“Combination of Liquid Chromatography-Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometry with 13C-labeling for Chemical Assignment of Sulfur-containing Metabolites in Onion Bulbs”